Cellular Ageing and Senescence Laboratory
WHAT WE DO
We study gene and protein networks implicated in cellular fitness and metabolism, neurodegeneration, cancer and ageing with a focus on the nutrient-responsive signalling pathway Target of Rapamycin (TOR).
Our aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases. In addition, the group performs quantitative fitness profiling of microbiomes and mycobiomes and explore the effects of nutrition on biome physiology and subsequent effects on human healthy ageing. We use the fission Schizosaccharomyces pombe and mammalian 2D and 3D tissue culture systems and utilise multi-omics approaches and network biology.